Materials fell the most, down 1.2%, while real estate led the gains, up 0.9%. Shares of Biogen surged 38.3% on news that the Food and Drug Administration approved its Alzheimer’s disease drug, aducanumab. So-called ‘meme’ stocks remained in focus with shares in AMC Entertainment up 14.8%. At the close of trade, the Dow was lower by 126 points or 0.4%. The S&P 500 index fell by 0.1%. But the Nasdaq index was up by 67 points or 0.5%.