Investors turned cautious after explosions in Afghanistan with reports of US military and Afghan civilian casualties. Sentiment was also dampened by comments from three of the US Federal Reserve’s non-voting regional Presidents -Esther George, Robert Kaplan and James Bullard -urging the central bank to start tapering its asset purchase program. Shares of Salesforce.com rose by 2.7% after strong June quarter earnings. But shares of discount retailer Dollar Tree shed 12.1% as rising freight costs hit its profit forecasts. The Dow Jones index fell by 192 points or 0.5%. The S&P 500 index lost 0.6% and the Nasdaq index slid 96 points or 0.6%.